Projects

This project describes a simulation of an industrial-scale fed-batch fermentation that can be used as a benchmark in process systems analysis and control studies. The simulation was developed using a mechanistic model and validated using historical data collected from an industrial-scale penicillin fermentation process. Each batch was carried out in a 100,000 L bioreactor that used an industrial strain of Penicillium chrysogenum. The manipulated variables recorded during each batch were used as ...

Industrial-scale penicillin simulation (IndPenSim) is a first principles mathematical model of a Penicillium chrysogenum fermentation. The simulation was developed in Matlab and is freely available to download. The development of the simulation is discussed in the paper titled "The development of an industrial-scale fed-batch fermentation simulation" currently available to download: here (Journal of Biotechnology). The paper has recently been extended which include the addition of a simulated ...

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