Katy Wolstencroft

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About Katy Wolstencroft:

No description specified

SEEK ID: https://sandbox7.fairdomhub.org/people/17

Location: Netherlands

ORCID: https://orcid.org/0000-0002-1279-5133

Joined: 27th Feb 2026

Expertise: Bioinformatics, Data Management, FAIR

Tools: Not specified

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metagenomics

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ACDC ISA

Exploring ISA for omics and imaging

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TDCC Integration

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Public web page: https://tdcc.nl/projects/tdcc-lsh-project-initiatives/tdcc-lsh-fair-fellowship-programme-building-a-network-of-experts-for-responsible-handling-of-digital-research-data/

Organisms: Saccharomyces cerevisiae

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Amsterdam University Medical Centers

ROR ID: https://ror.org/05grdyy37

Department: Not specified

Country: Netherlands

City: Amsterdam

Web page: https://www.amsterdamumc.org

Advanced Compute and Data Core, Amsterdam University Medical Centers

ROR ID: https://ror.org/05grdyy37

Department: Advanced Compute and Data Core

Country: Netherlands

City: Amsterdam

Web page: https://www.amsterdamumc.org

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Detection of large numbers of novel sequences in the metatranscriptomes of complex marine microbial communities.

TDCC Integration

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BACKGROUND: Sequencing the expressed genetic information of an ecosystem (metatranscriptome) can provide information about the response of organisms to varying environmental conditions. Until recently, …

Authors: J. A. Gilbert, D. Field, Y. Huang, R. Edwards, W. Li, P. Gilna, I. Joint

Date Published: 22nd Aug 2008

Publication Type: Journal Article

PubMed ID: 18725995

Citation: PLoS One. 2008 Aug 22;3(8):e3042. doi: 10.1371/journal.pone.0003042.

Created: 2nd Mar 2026 at 05:33

Growth control of the eukaryote cell: a systems biology study in yeast

TDCC Integration

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Abstract Background Cell growth underlies many key cellular and developmental processes, yet a limited number of studies have been carried out on cell-growth regulation. Comprehensive studies at the …out on cell-growth regulation. Comprehensive studies at the transcriptional, proteomic and metabolic levels under defined controlled conditions are currently lacking. Results Metabolic control analysis is being exploited in a systems biology study of the eukaryotic cell. Using chemostat culture, we have measured the impact of changes in flux (growth rate) on the transcriptome, proteome, endometabolome and exometabolome of the yeast Saccharomyces cerevisiae . Each functional genomic level shows clear growth-rate-associated trends and discriminates between carbon-sufficient and carbon-limited conditions. Genes consistently and significantly upregulated with increasing growth rate are frequently essential and encode evolutionarily conserved proteins of known function that participate in many protein-protein interactions. In contrast, more unknown, and fewer essential, genes are downregulated with increasing growth rate; their protein products rarely interact with one another. A large proportion of yeast genes under positive growth-rate control share orthologs with other eukaryotes, including humans. Significantly, transcription of genes encoding components of the TOR complex (a major controller of eukaryotic cell growth) is not subject to growth-rate regulation. Moreover, integrative studies reveal the extent and importance of post-transcriptional control, patterns of control of metabolic fluxes at the level of enzyme synthesis, and the relevance of specific enzymatic reactions in the control of metabolic fluxes during cell growth. Conclusion This work constitutes a first comprehensive systems biology study on growth-rate control in the eukaryotic cell. The results have direct implications for advanced studies on cell growth, in vivo regulation of metabolic fluxes for comprehensive metabolic engineering, and for the design of genome-scale systems biology models of the eukaryotic cell.

Authors: Juan I Castrillo, Leo A Zeef, David C Hoyle, Nianshu Zhang, Andrew Hayes, David CJ Gardner, Michael J Cornell, June Petty, Luke Hakes, Leanne Wardleworth, Bharat Rash, Marie Brown, Warwick B Dunn, David Broadhurst, Kerry O'Donoghue, Svenja S Hester, Tom PJ Dunkley, Sarah R Hart, Neil Swainston, Peter Li, Simon J Gaskell, Norman W Paton, Kathryn S Lilley, Douglas B Kell, Stephen G Oliver